Loopy Determinations of $V_{ub}$ and $V_{cb}$

We use loop induced processes like meson oscillations and rare b hadron decays to determine the absolute values of the CKM matrix elements $|V_{ub}|$ and $|V_{cb}|$ and compare our results to the standard determinations based on inclusive and exclusive semileptonic tree-level decays of B mesons. For many years there have been tensions between the inclusive and exclusive determinations. Assuming the absence of new physics, we find that meson oscillation data shows a slight preference for the inclusive value of $|V_{cb}|$ and the exclusive value for $|V_{ub}|$. Rare b decay data prefers values for $|V_{cb}|$ far below the inclusive and exclusive determinations, offering a new perspective on some of the persistent rare b decay anomalies.