Local stabilizability implies global controllability in catalytic reaction systems
Abstract
Controlling complex reaction networks is a fundamental challenge in the fields of physics, biology, and systems engineering. Here, we prove a general principle for catalytic reaction systems with kinetics where the reaction order and the stoichiometric coefficient match: the local stabilizability of a given state implies global controllability within its stoichiometric compatibility class. In other words, if a target state can be maintained against small perturbations, the system can be controlled from any initial condition to that state. This result highlights a tight link between the local and global dynamics of nonlinear chemical reaction systems, providing a mathematical criterion for global reachability that is often elusive in high-dimensional systems. The finding illuminate the robustness of biochemical systems and offers a way to control catalytic reaction systems in a generic framework.
Cite
@article{arxiv.2505.06834,
title = {Local stabilizability implies global controllability in catalytic reaction systems},
author = {Yusuke Himeoka and Shuhei A. Horiguchi and Naoto Shiraishi and Fangzhou Xiao and Tetsuya J. Kobayashi},
journal= {arXiv preprint arXiv:2505.06834},
year = {2026}
}