The Laser Interferometer Space Antenna (LISA) will observe gravitational radiation in the milliHertz band by measuring picometer-level fluctuations in the distance between drag-free proof masses over baselines of approximately five million kilometers. The measurement over each baseline will be divided into three parts: two short-arm measurements between the proof masses and a fiducial point on their respective spacecraft, and a long-arm measurement between fiducial points on separate spacecraft. This work focuses on the technical challenges associated with these long-arm measurements and the techniques that have been developed to overcome them.