Learning of signaling networks: molecular mechanisms
Abstract
Molecular processes of neuronal learning have been well-described. However, learning mechanisms of non-neuronal cells have not been fully understood at the molecular level. Here, we discuss molecular mechanisms of cellular learning, including conformational memory of intrinsically disordered proteins and prions, signaling cascades, protein translocation, RNAs (microRNA and lncRNA), and chromatin memory. We hypothesize that these processes constitute the learning of signaling networks and correspond to a generalized Hebbian learning process of single, non-neuronal cells, and discuss how cellular learning may open novel directions in drug design and inspire new artificial intelligence methods.
Cite
@article{arxiv.2001.11679,
title = {Learning of signaling networks: molecular mechanisms},
author = {Péter Csermely and Nina Kunsic and Péter Mendik and Márk Kerestély and Teodóra Faragó and Dániel V. Veres and Péter Tompa},
journal= {arXiv preprint arXiv:2001.11679},
year = {2020}
}
Comments
cover story of the 2020 April issue of Trends in Biochemical Sciences