English

Kinetoplast DNA: a polymer physicist's Olympic dream

Soft Condensed Matter 2024-08-13 v1 Biological Physics

Abstract

All life forms are miraculous, but some are more inexplicable than others. Trypanosomes are by far one of the most puzzling organisms on Earth: their mitochondrial genome, also called kinetoplast DNA (kDNA) forms an Olympic-ring-like network of interlinked DNA circles, challenging conventional paradigms in both biology and physics. In this review, I will discuss kDNA from the astonished perspective of a polymer physicist and tell a story of how a single sub-celluar structure from a blood-dwelling parasite is inspiring generations of polymer chemists and physicists to create new catenated materials.

Cite

@article{arxiv.2408.05978,
  title  = {Kinetoplast DNA: a polymer physicist's Olympic dream},
  author = {Davide Michieletto},
  journal= {arXiv preprint arXiv:2408.05978},
  year   = {2024}
}

Comments

review paper on kDNA

R2 v1 2026-06-28T18:10:09.939Z