Nanocomposite material (GGAG:Ce3+@SiO2−RB) for potential use in X-ray induced photodynamic therapy (X-PDT) was developed, thoroughly characterized, and evaluated. It consists of a scintillating Gd3(Ga1−xAlx)5O12:Ce3+ core encapsulated in silica layer and functionalized with the photosensitizer Rose Bengal (RB). Radioluminescence measurements confirmed the energy transfer from the scintillating core to Rose Bengal. Dark toxicity and radiosensitisation effects were evaluated using Saccharomyces cerevisiae as a model organism. The nanocomposite showed minimal dark toxicity at concentrations of up to 10 mg/mL. However, X-ray irradiation experiments did not demonstrate significant singlet oxygen production compared to the controls. Although the nanocomposite design shows potential, further optimization is needed to achieve an effective X-PDT performance.
@article{arxiv.2505.20358,
title = {Is GGAG:Ce@SiO$_2$-RB composite a prospective material for X-ray induced photodynamic therapy?},
author = {Iveta Terezie Hošnová and Kristýna Havlinová and Jan Bárta and Karolína Mocová and Xenie Lytvynenko and Lenka Prouzová Procházková and Vojtěch Kazda and František Hájek and Viliam Múčka and Václav Čuba},
journal= {arXiv preprint arXiv:2505.20358},
year = {2025}
}