English

Invasion by rare mutants in a spatial two-type Fisher-Wright system with selection

Probability 2011-04-05 v1

Abstract

We consider a meanfield system of interacting Fisher-Wright diffusions with selection and rare mutation on the geographic space {1,2,...,N}\{1,2,...,N\}. The type 1 has fitness 0, type 2 has fitness 1 and (rare) mutation occurs from type 1 to 2 at rate m...N1m...N^{-1}, selection is at rate s>0s>0. The system starts in the state concentrated on type 1, the state of low fitness. We investigate this system for NN \to \infty on the original and large time scales. We show that for some α(0,s)\alpha \in (0,s) at times α1logN+t,tR,N\alpha^{-1} \log N+t, t \in \R, N \to \infty the emergence of type 2 (positive global type-2 intensity) at a global level occurs, while at times α1logN+tN\alpha^{-1} \log N+t_N, with tNt_N \to \infty we get fixation on type 2 and on the other hand with tNt_N \to -\infty as NN \to \infty asymptotically only type 1 is present. We describe the transition from emergence to fixation in the time scale α1logN+t,tR\alpha^{-1} \log N+t, t \in \R in the limit NN \to \infty by a McKean-Vlasov random entrance law. This entrance law behaves for tt \to -\infty like \CWeαt^\ast\CW e^{-\alpha |t|} for a positive random variable \CW^\ast \CW. The formation of small droplets of type-2 dominated sites in times o(logN)o(\log N), or γ...logN,γ(0,α1)\gamma...\log N, \gamma \in (0,\alpha^{-1}) is described in the limit NN \to \infty by a measure-valued process following a stochastic equation driven by Poissonian type noise which we identify explicitly. The total mass of this limiting (N)(N \to \infty) droplet process grows like \CWeαt\CW^\ast e^{\alpha t} as tt \to \infty. We prove that exit behaviour from the small time scale equals the entrance behaviour in the large time scale, namely \CL[\CW]=\CL[\CW]\CL[^\ast\CW] =\CL[\CW^\ast].

Keywords

Cite

@article{arxiv.1104.0253,
  title  = {Invasion by rare mutants in a spatial two-type Fisher-Wright system with selection},
  author = {Donald A. Dawson and Andreas Greven},
  journal= {arXiv preprint arXiv:1104.0253},
  year   = {2011}
}

Comments

186 pages

R2 v1 2026-06-21T17:48:27.284Z