English

Interchromatidal central ridge and transversal symmetry in early metaphasic human chromosome one

Genomics 2008-03-07 v1

Abstract

The topographic structure of Giemsa banded (G-banded) early metaphase human chromosomes adsorbed on glass was analyzed by atomic force microscope using amplitude modulation mode [AM-AFM]. Longitudinal height measurements for early metaphasic human chromosomes showed a central ridge that was further characterized by transversal height measurements. The heterochromatic regions displayed a high level of transversal symmetry, while the euchromatic ones presented several peaks across the transversal height measurements. We suggest that this central ridge and symmetry patterns point out a transitional arrangement of the early metaphase chromosome and support evidence for interchromatidal interactions prior to disjunction.

Keywords

Cite

@article{arxiv.0803.0964,
  title  = {Interchromatidal central ridge and transversal symmetry in early metaphasic human chromosome one},
  author = {O. Argüello-Miranda and G. Sáenz-Arce},
  journal= {arXiv preprint arXiv:0803.0964},
  year   = {2008}
}