Combining extensive single particle tracking microscopy data of endogenous lipid granules in living fission yeast cells with analytical results we show evidence for anomalous diffusion and weak ergodicity breaking. Namely we demonstrate that at short times the granules perform subdiffusion according to the laws of continuous time random walk theory. The associated violation of ergodicity leads to a characteristic turnover between two scaling regimes of the time averaged mean squared displacement. At longer times the granule motion is consistent with fractional Brownian motion.
@article{arxiv.1010.0347,
title = {In vivo anomalous diffusion and weak ergodicity breaking of lipid granules},
author = {Jae-Hyung Jeon and Vincent Tejedor and Stas Burov and Eli Barkai and Christine Selhuber-Unkel and Kirstine Berg-Sorensen and Lene Oddershede and Ralf Metzler},
journal= {arXiv preprint arXiv:1010.0347},
year = {2015}
}