We investigate usage of dynamic time warping (DTW) algorithm for aligning raw signal data from MinION sequencer. DTW is mostly using for fast alignment for selective sequencing to quickly determine whether a read comes from sequence of interest. We show that standard usage of DTW has low discriminative power mainly due to problem with accurate estimation of scaling parameters. We propose a simple variation of DTW algorithm, which does not suffer from scaling problems and has much higher discriminative power.
Cite
@article{arxiv.1705.01620,
title = {Improving Nanopore Reads Raw Signal Alignment},
author = {Vladimír Boža and Broňa Brejová and Tomáš Vinař},
journal= {arXiv preprint arXiv:1705.01620},
year = {2017}
}