English

Improved statistical benchmarking of digital pathology models using pairwise frames evaluation

Computer Vision and Pattern Recognition 2023-06-09 v1 Machine Learning

Abstract

Nested pairwise frames is a method for relative benchmarking of cell or tissue digital pathology models against manual pathologist annotations on a set of sampled patches. At a high level, the method compares agreement between a candidate model and pathologist annotations with agreement among pathologists' annotations. This evaluation framework addresses fundamental issues of data size and annotator variability in using manual pathologist annotations as a source of ground truth for model validation. We implemented nested pairwise frames evaluation for tissue classification, cell classification, and cell count prediction tasks and show results for cell and tissue models deployed on an H&E-stained melanoma dataset.

Keywords

Cite

@article{arxiv.2306.04709,
  title  = {Improved statistical benchmarking of digital pathology models using pairwise frames evaluation},
  author = {Ylaine Gerardin and John Shamshoian and Judy Shen and Nhat Le and Jamie Prezioso and John Abel and Isaac Finberg and Daniel Borders and Raymond Biju and Michael Nercessian and Vaed Prasad and Joseph Lee and Spencer Wyman and Sid Gupta and Abigail Emerson and Bahar Rahsepar and Darpan Sanghavi and Ryan Leung and Limin Yu and Archit Khosla and Amaro Taylor-Weiner},
  journal= {arXiv preprint arXiv:2306.04709},
  year   = {2023}
}

Comments

10 pages, 7 figures

R2 v1 2026-06-28T10:59:17.332Z