Impact of Short- and Long-range Forces on Protein Conformation and Adsorption Kinetics
Soft Condensed Matter
2007-05-23 v2
Abstract
We have studied the adsorption kinetics of the protein amylase at solid/liquid interfaces. Offering substrates with tailored properties, we are able to separate the impact of short- and long-range interactions. By means of a colloidal Monte Carlo approach including conformational changes of the adsorbed proteins induced by density fluctuations, we develop a scenario that is consistent with the experimentally observed three-step kinetics on specific substrates. Our observations show that not only the surface chemistry determines the properties of an adsorbed protein layer but also the van der Waals contributions of a composite substrate may lead to non-negligible effects.
Keywords
Cite
@article{arxiv.cond-mat/0607384,
title = {Impact of Short- and Long-range Forces on Protein Conformation and Adsorption Kinetics},
author = {Anthony Quinn and Hubert Mantz and Karin Jacobs and Markus Bellion and Ludger Santen},
journal= {arXiv preprint arXiv:cond-mat/0607384},
year = {2007}
}
Comments
6 pages, 5 figures, revised version