Hyperpolarized Long-T1 Silicon Nanoparticles for Magnetic Resonance Imaging
Materials Science
2009-12-22 v1 Mesoscale and Nanoscale Physics
Abstract
Silicon nanoparticles are experimentally investigated as a potential hyperpolarized, targetable MRI imaging agent. Nuclear T_1 times at room temperature for a variety of Si nanoparticles are found to be remarkably long (10^2 to 10^4 s) - roughly consistent with predictions of a core-shell diffusion model - allowing them to be transported, administered and imaged on practical time scales without significant loss of polarization. We also report surface functionalization of Si nanoparticles, comparable to approaches used in other biologically targeted nanoparticle systems.
Keywords
Cite
@article{arxiv.0902.0269,
title = {Hyperpolarized Long-T1 Silicon Nanoparticles for Magnetic Resonance Imaging},
author = {J. W. Aptekar and M. C. Cassidy and A. C. Johnson and R. A. Barton and M. Y. Lee and A. C. Ogier and C. Vo and M. N. Anahtar and Y. Ren and S. N. Bhatia and C. Ramanathan and D. G. Cory and A. L. Hill and R. W. Mair and M. S. Rosen and R. L. Walsworth and C. M. Marcus},
journal= {arXiv preprint arXiv:0902.0269},
year = {2009}
}
Comments
supporting material here: http://marcuslab.harvard.edu/Aptekar_hyper1_sup.pdf