How to observe the QCD instanton/sphaleron processes at hadron colliders?

The instanton/sphaleron processes involve gauge fields with changing topology through a nonzero variation of the Chern-Simons number $\delta N_{CS}=\pm 1$. In QCD this leads to the production of $2N_f \delta N_{CS}$ units of axial charge, and in the electroweak theory to the production of 12 fermions, with $\Delta B=\delta L=3$ units of baryon and lepton number, a key mechanism in baryogenesis. While this is all known for a long time, and is one of the pillars of the nonperturbative theory of the QCD vacuum, to see these phenomena directly in colliders remains an unfulfilled promise. Motivated by the recent CERN workshop on the topic, we review the field. We also put forward our own suggestions to utilize double-diffractive (or Pomeron-Pomeron) collisions to this goal, which maximizes the entrance factor and minimizes the backgrounds. We consider separately clusters of small ($M=3-10\, {\rm GeV}$), medium ($10-30\, {\rm GeV}$) and high $M\sim 100 \, {\rm GeV}$ invariant masses. Among the proposed signals are specific flavor combination of channels, originating from well-defined 6-, 8- and 10-quark-antiquark operators, as well as correlation of quark chiralities to be potentially detected via $\Lambda$ hyperon decays.