Haplotype Assembly Using Manifold Optimization and Error Correction Mechanism
Optimization and Control
2019-04-16 v2 Signal Processing
Abstract
Recent matrix completion based methods have not been able to properly model the Haplotype Assembly Problem (HAP) for noisy observations. To cope with such a case, in this letter we propose a new Minimum Error Correction (MEC) based matrix completion optimization problem over the manifold of rank-one matrices. The convergence of a specific iterative algorithm for solving this problem is proved. Simulation results illustrate that the proposed method not only outperforms some well-known matrix completion based methods, but also presents a more accurate result compared to a most recent MEC based algorithm for haplotype estimation.
Cite
@article{arxiv.1901.00136,
title = {Haplotype Assembly Using Manifold Optimization and Error Correction Mechanism},
author = {Mohamad Mahdi Mohades and Sina Majidian and Mohammad Hossein Kahaei},
journal= {arXiv preprint arXiv:1901.00136},
year = {2019}
}