Growth and Elasticity of Mechanically-Created Neurites
Biological Physics
2019-12-13 v1
Abstract
Working in the framework of morphoelasticity, we develop a model of neurite growth in response to elastic deformation. We decompose the applied stretch into an elastic component and a growth component, and adopt an observationally-motivated model for the growth law. We then compute the best-fit model parameters by fitting to force-extension curves from measurements of constant-speed uniaxial deformations of mechanically-induced neurites of rat hippocampal neurons. We find a time constant for the growth law of 0.009~s, similar to the diffusion rate of actin in a cell. Our results characterize the kinematics of neurite growth and establish new limits on the growth rate of neurites.
Keywords
Cite
@article{arxiv.1912.05735,
title = {Growth and Elasticity of Mechanically-Created Neurites},
author = {Madeleine Anthonisen and Peter Grutter},
journal= {arXiv preprint arXiv:1912.05735},
year = {2019}
}
Comments
8 pages, 7 figures