Group actions, corks and exotic smoothings of R^4

We provide the first information on diffeotopy groups of exotic smoothings of R^4: For each of uncountably many smoothings, there are uncountably many isotopy classes of self-diffeomorphisms. We realize these by various explicit group actions. There are also actions at infinity by nonfinitely generated groups, for which no nontrivial element extends over the whole manifold. In contrast, every diffeomorphism of the end of the universal R^4 extends. Our techniques apply to many other open 4-manifolds, and are related to cork theory. We show that under broad hypotheses, cork twisting is equivalent (up to blowups) to twisting on an exotic R^4, and give applications.