Diffuse Large B-cell Lymphoma (DLBCL) is a lymphatic cancer involving one or more lymph nodes and extranodal sites. Its diagnostic and follow-up rely on Positron Emission Tomography (PET) and Computed Tomography (CT). After diagnosis, the number of nonresponding patients to standard front-line therapy remains significant (30-40%). This work aims to develop a computer-aided approach to identify high-risk patients requiring adapted treatment by efficiently exploiting all the information available for each patient, including both clinical and image data. We propose a method based on recent graph neural networks that combine imaging information from multiple lesions, and a cross-attention module to integrate different data modalities efficiently. The model is trained and evaluated on a private prospective multicentric dataset of 583 patients. Experimental results show that our proposed method outperforms classical supervised methods based on either clinical, imaging or both clinical and imaging data for the 2-year progression-free survival (PFS) classification accuracy.
@article{arxiv.2310.16863,
title = {Graph-based multimodal multi-lesion DLBCL treatment response prediction from PET images},
author = {Oriane Thiery and Mira Rizkallah and Clément Bailly and Caroline Bodet-Milin and Emmanuel Itti and René-Olivier Casasnovas and Steven Le Gouill and Thomas Carlier and Diana Mateus},
journal= {arXiv preprint arXiv:2310.16863},
year = {2023}
}