Glassy dynamics and memory effects in an intrinsically disordered protein construct
Soft Condensed Matter
2020-07-30 v1 Biological Physics
Abstract
Glassy, nonexponential relaxations in globular proteins are typically attributed to conformational behaviors that are missing from intrinsically disordered proteins. Yet, we show that single molecules of a disordered-protein construct display two signatures of glassy dynamics, logarithmic relaxations and a Kovacs memory effect, in response to changes in applied tension. We attribute this to the presence of multiple independent local structures in the chain, which we corroborate with a model that correctly predicts the force dependence of the relaxation. The mechanism established here likely applies to other disordered proteins.
Keywords
Cite
@article{arxiv.2007.10404,
title = {Glassy dynamics and memory effects in an intrinsically disordered protein construct},
author = {Ian L. Morgan and Ram Avinery and Gil Rahamim and Roy Beck and Omar A. Saleh},
journal= {arXiv preprint arXiv:2007.10404},
year = {2020}
}
Comments
6 pages, 3 figures, accepted for publication in Physical Review Letters