Functionality and Protein-Water Interactions
Soft Condensed Matter
2008-03-04 v1
Abstract
The structures of proteins exhibit secondary elements composed of helices and loops. Comparison of several water-only hydrophobicity scales with the functionalities of two repeat proteins shows that these secondary elements possess water-induced medium-range order that is sometimes similar, but can also be complementary, to structural order. Study of these hitherto "phantom" order parameters promises far-reaching incremental improvements in the theory of protein dynamics. A by-product of the theory is an independent evaluation of the reliability of different hydrophobicity scales.
Cite
@article{arxiv.0803.0091,
title = {Functionality and Protein-Water Interactions},
author = {J. C. Phillips},
journal= {arXiv preprint arXiv:0803.0091},
year = {2008}
}