Foliations, solvability and global injectivity

Let $F: \mathbb{R}^n\to\mathbb{R}^n$ be a $C^{\infty}$ map such that $DF(x)$ is invertible for every $x\in\mathbb{R}^n$. Although being a local diffeomorphism, $F$ is not necessarily globally injective if $n\geq2$. Finding additional assumptions implying the global injectivity of $F$ for $n\geq 2$ is object of intense study in several areas of Mathematics. In this paper we revisit some assumptions and relations between them in the bidimensional case and discuss the natural higher dimensional situation.