This paper considers the fixed-time control problem of a multi-agent system composed of a class of Euler-Lagrange dynamics with parametric uncertainty and a dynamic leader under a directed communication network. A distributed fixed-time observer is first proposed to estimate the desired trajectory and then a fixed-time controller is constructed by transforming uncertain Euler-Lagrange systems into second-order systems and utilizing the backstepping design procedure. The overall design guarantees that the synchronization errors converge to zero in a prescribed time independent of initial conditions. The control design conditions can also be relaxed for a weaker finite-time control requirement.