First observation of $\psi(2S) \to p \bar{n} \pi^- +c.c.$

Using 14 million $\psi(2S)$ events collected with the Beijing Spectrometer (BESII) at the Beijing Electron-Positron Collider, the branching fractions of $\psi(2S)$ decays to $p \bar{n} \pi^-$ and $\bar{p} n \pi^+$ and the branching fractions of the main background channels $\psi(2S) \to p \bar{n} \pi^-\pi^0$, $\psi(2S) \to \gamma\chi_{c0} \to \gamma p \bar{n} \pi^-$, $\psi(2S) \to \gamma\chi_{c2} \to \gamma p \bar{n} \pi^-$, and $\psi(2S) \to \gamma \chi_{cJ} \to \gamma p \bar{n} \pi^- \pi^0$ are determined. The contributions of the $N^{\ast}$ resonances in $\psi(2S) \to p \bar{n} \pi^- +c.c.$ are also discussed.