One of many important features of the tumour microenvironment is that it is a place of active Darwinian selection where different tumour clones become adapted to the variety of ecological niches that make up the microenvironment. These evolutionary processes turn the microenvironment into a powerful source of tumour heterogeneity and contribute to the development of drug resistance in cancer. Here, we describe a computational tool to study the ecology of the microenvironment and report results about the ecology of the tumour microenvironment and its evolutionary dynamics.
@article{arxiv.1906.02441,
title = {Fine-grained simulations of the microenvironment of vascularized tumours},
author = {Thierry Fredrich and Heiko Rieger and Roberto Chignola and Edoardo Milotti},
journal= {arXiv preprint arXiv:1906.02441},
year = {2019}
}