Families of periodic orbits: closed 1-forms and global continuability

We investigate global continuation of periodic orbits of a differential equation depending on a parameter, assuming that a closed 1-form satisfying certain properties exists. We begin by extending the global continuation theory of Alexander, Alligood, Mallet-Paret, Yorke, and others to this situation, formulating a new notion of global continuability and a new global continuation theorem tailored for this situation. In particular, we show that the existence of such a 1-form ensures that local continuability of periodic orbits implies global continuability. Using our general theory, we then develop continuation-based techniques for proving the existence of periodic orbits. In contrast to previous work, a key feature of our results is that existence of periodic orbits can be proven (i) without finding trapping regions for the dynamics and (ii) without establishing a priori upper bounds on the periods of orbits. We illustrate the theory in examples inspired by the synthetic biology literature.