Extreme value analysis of gut microbial alterations in colorectal cancer
Quantitative Methods
2019-03-27 v3
Abstract
Gut microbes play a key role in colorectal carcinogenesis, yet reaching a consensus on microbial signatures remains a challenge. This is in part due to a reliance on mean value estimates. We present an extreme value analysis for overcoming these limitations. By characterizing a power law fit to the relative abundances of microbes, we capture the same microbial signatures as more complex meta-analyses. Importantly, we show that our method is robust to the variations inherent in microbial community profiling and point to future directions for developing sensitive, reliable analytical methods.
Cite
@article{arxiv.1807.09400,
title = {Extreme value analysis of gut microbial alterations in colorectal cancer},
author = {Stephanie Danni Song and Patricio Jeraldo and Jun Chen and Nicholas Chia},
journal= {arXiv preprint arXiv:1807.09400},
year = {2019}
}