Expiratory variability index (EVI) is associated with asthma risk, wheeze and lung function in infants with recurrent respiratory symptoms

Ville-Pekka Seppä; Javier Gracia-Tabuenca; Anne Kotaniemi-Syrjänen; Kristiina Malmström; Anton Hult; Anna Pelkonen; Mika J. Mäkelä; Jari Viik; L. Pekka Malmberg

Expiratory variability index (EVI) is associated with asthma risk, wheeze and lung function in infants with recurrent respiratory symptoms

Quantitative Methods 2020-08-28 v1 Medical Physics

Authors: Ville-Pekka Seppä , Javier Gracia-Tabuenca , Anne Kotaniemi-Syrjänen , Kristiina Malmström , Anton Hult , Anna Pelkonen , Mika J. Mäkelä , Jari Viik , L. Pekka Malmberg

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Abstract

Recurrent respiratory symptoms are common in infants but the paucity of lung function tests suitable for routine use in infants is a widely acknowledged clinical problem. In this study we evaluated tidal breathing variability (expiratory variability index, EVI) measured at home during sleep using impedance pneumography (IP) as a marker of lower airway obstruction in 36 infants (mean age 12.8 [range 6-23] months) with recurrent respiratory symptoms. Lowered EVI was associated with lower lung function (VmaxFRC), higher asthma risk, and obstructive symptoms, but not with nasal congestion. EVI measured using IP is a potential technique for lung function testing in infants.

Keywords

expiratory variability index infant lung function asthma risk impedance pneumography recurrent respiratory symptoms

Cite

@article{arxiv.2008.11718,
  title  = {Expiratory variability index (EVI) is associated with asthma risk, wheeze and lung function in infants with recurrent respiratory symptoms},
  author = {Ville-Pekka Seppä and Javier Gracia-Tabuenca and Anne Kotaniemi-Syrjänen and Kristiina Malmström and Anton Hult and Anna Pelkonen and Mika J. Mäkelä and Jari Viik and L. Pekka Malmberg},
  journal= {arXiv preprint arXiv:2008.11718},
  year   = {2020}
}

Expiratory variability index (EVI) is associated with asthma risk, wheeze and lung function in infants with recurrent respiratory symptoms

Abstract

Keywords

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