Existence and uniqueness of global large-data solutions for the Chemotaxis-Navier-Stokes system in $\mathbb{R}^2$

This work investigates the Cauchy problem for the classical Chemotaxis-Navier-Stokes (CNS) system in $\mathbb{R}^2$. We establish the global existence and uniqueness of strong, classical, and arbitrarily smooth solutions under large initial data, which has not been addressed in the existing literature. The key idea is to first derive an entropy-energy estimate for initial data with low regularity, by leveraging the intrinsic entropy structure of the system. Building on this foundation, we then obtain higher-order energy estimates for smoother initial data via a bootstrap argument, in which the parabolic nature of the CNS system plays a crucial role in the iterative control of regularity.