Exact Solution of the Munoz-Eaton Model for Protein Folding
Statistical Mechanics
2009-11-07 v1 Soft Condensed Matter
q-bio
Abstract
A transfer-matrix formalism is introduced to evaluate exactly the partition function of the Munoz-Eaton model, relating the folding kinetics of proteins of known structure to their thermodynamics and topology. This technique can be used for a generic protein, for any choice of the energy and entropy parameters, and in principle allows the model to be used as a first tool to characterize the dynamics of a protein of known native state and equilibrium population. Applications to a -hairpin and to protein CI-2, with comparisons to previous results, are also shown.
Cite
@article{arxiv.cond-mat/0205646,
title = {Exact Solution of the Munoz-Eaton Model for Protein Folding},
author = {Pierpaolo Bruscolini and Alessandro Pelizzola},
journal= {arXiv preprint arXiv:cond-mat/0205646},
year = {2009}
}
Comments
4 pages, 5 figures, RevTeX 4. To be published in Phys. Rev. Lett