Evolutionary advantage of cell size control
Biological Physics
2023-03-15 v1 Statistical Mechanics
Populations and Evolution
Abstract
We analyze the advantage of cell size control strategies in growing populations under mortality constraints. We demonstrate a general advantage of the adder control strategy in the presence of growth-dependent mortality, and for different size-dependent mortality landscapes. Its advantage stems from epigenetic heritability of cell size, which enables selection to act on the distribution of cell sizes in a population to avoid mortality thresholds and adapt to a mortality landscape.
Keywords
Cite
@article{arxiv.2303.08042,
title = {Evolutionary advantage of cell size control},
author = {Spencer Hobson-Gutierrez and Edo Kussell},
journal= {arXiv preprint arXiv:2303.08042},
year = {2023}
}