I present estimates of the branching fractions in the non-leptonic charmonium two-body decay rates for B0→ψ(2S)π0 decay and the same decays of B+→ψ(2S)π+, B0→ψ(2S)K0 and B+→ψ(2S)K+. These estimates are based on a generalized factorization approach making use of leading order (LO) and next-to-leading order (NLO) contributions. I find that when the large enhancements from the known NLO contributions by using the QCD factorization approach are taken into account, the branching ratios are the following: Br(B0→ψ(2S)π0)=(1.067±0.059)×10−5, Br(B+→ψ(2S)π+)=(2.134±0.0.118)×10−5, Br(B0→ψ(2S)K0)=(6.344±0.376)×10−4 and Br(B+→ψ(2S)K+)=(6.344±0.376)×10−4, while the experimental results are (1.17±0.17)×10−5, (2.44±0.30)×10−5, (6.20±0.50)×10−4 and (6.39±0.33)×10−4 respectively. All estimates are in good agreement with the experimental results.