Escape from crossover interference increases with maternal age
Abstract
Recombination plays a fundamental role in meiosis, ensuring the proper segregation of chromosomes and contributing to genetic diversity by generating novel combinations of alleles. Using data derived from directUtoUconsumer genetic testing, we investigated patterns of recombination in over 4,200 families. Our analysis revealed a number of sex differences in the distribution of recombination. We find the fraction of male events occurring within hotspots to be 4.6% higher than for females. We confirm that the recombination rate increases with maternal age, while hotspot usage decreases, with no such effects observed in males. Finally, we show that the placement of female recombination events becomes increasingly deregulated with maternal age, with an increasing fraction of events appearing to escape crossover interference.
Keywords
Cite
@article{arxiv.1408.5517,
title = {Escape from crossover interference increases with maternal age},
author = {Christopher L. Campbell and Nicholas A. Furlotte and Nick Eriksson and David Hinds and Adam Auton},
journal= {arXiv preprint arXiv:1408.5517},
year = {2015}
}
Comments
47 pages, 18 figures