Entropy Transfer Throughout the Structure of PDZ-2 and TIM-Barrel Proteins. A Dynamic Gaussian Network Model Study
Biomolecules
2025-11-21 v1
Abstract
This research reports the entropy transfer throughout the tridimensional structure of PDZ-2 and TIM barrel structures using the dynamic Gaussian Network Model. The model predicts the allocation of the allosteric pathways of the PDZ-2. Moreover. A visualization analysis reveals that entropy and information is transported towards the effector site in PDZ-2 and near to the catalytic site of the TIM-Barrel protein. The results suggest the presence of a functional hierarchy that determine information and entropy flow directionality.
Cite
@article{arxiv.2511.16456,
title = {Entropy Transfer Throughout the Structure of PDZ-2 and TIM-Barrel Proteins. A Dynamic Gaussian Network Model Study},
author = {German Mino Galaz and Javier Patino Baez and Nicolas Mino Berdu and Jose Gonzalez Suarez},
journal= {arXiv preprint arXiv:2511.16456},
year = {2025}
}
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