The cosmogenic production of long-lived isotopes such as 3H,55Fe, 60Co, 65Zn, and 68Ge poses a significant challenge as a source of background events in Ge-based dark matter (DM) and neutrinoless double-beta decay (0νββ) experiments. In the pursuit of DM, particularly within the largely unexplored parameter space for low-mass DM, new detector technologies are being developed with extremely low-energy thresholds to detect MeV-scale DM. However, isotopes like 3H, 55Fe, 65Zn, and 68Ge, produced cosmogenically within the detector material, emerge as dominant backgrounds that severely limit sensitivity in these searches. Similarly, efforts to detect 0νββ, especially under a neutrino normal mass hierarchy scenario, require a sensitivity to the effective Majorana mass of ∼1 meV. Achieving this level of sensitivity necessitates stringent suppression of background signals from isotopes such as 60Co and 68Ge, which impose critical detection limits. To reach the targeted sensitivity for these next-generation experiments and to unlock their full discovery potential for both low-mass DM and 0νββ, relocating Ge crystal growth and detector fabrication to underground environments is crucial. This approach is the most effective strategy to significantly reduce the production of these long-lived isotopes, thereby ensuring the experimental sensitivity required for groundbreaking discoveries.