English

Empirical corrections and pair interaction energies in the fragment molecular orbital method

Chemical Physics 2018-08-01 v1

Abstract

The energy and analytic gradient are developed for FMO combined with the Hartree-Fock method augmented with three empirical corrections (HF-3c). The auxiliary basis set approach to FMO is extended to perform pair interaction energy decomposition analysis. The FMO accuracy is evaluated for several typical systems including 3 proteins. Pair interaction energies computed with different approaches in FMO are compared for a water cluster and protein-ligand complexes.

Keywords

Cite

@article{arxiv.1806.07628,
  title  = {Empirical corrections and pair interaction energies in the fragment molecular orbital method},
  author = {Dmitri G. Fedorov and Jimmy C. Kromann and Jan H. Jensen},
  journal= {arXiv preprint arXiv:1806.07628},
  year   = {2018}
}

Comments

Revised version accepted in Chemical Physics Letters