Effects of Sequence Disorder on DNA Looping and Cyclization
Abstract
Effects of sequence disorder on looping and cyclization of the double-stranded DNA are studied theoretically. Both random intrinsic curvature and inhomogeneous bending rigidity are found to result in a remarkably wide distribution of cyclization probabilities. For short DNA segments, the range of the distribution reaches several orders of magnitude for even completely random sequences. The ensemble averaged values of the cyclization probability are also calculated, and the connection to the recent experiments is discussed.
Keywords
Cite
@article{arxiv.cond-mat/0510302,
title = {Effects of Sequence Disorder on DNA Looping and Cyclization},
author = {Yuri O. Popov and Alexei V. Tkachenko},
journal= {arXiv preprint arXiv:cond-mat/0510302},
year = {2013}
}
Comments
8 pages, 4 figures, LaTeX; accepted to Physical Review E; v2: a substantially revised version; v3: references added, conclusions expanded, minor editorial corrections to the text; v4: a substantially revised and expanded version (total number of pages doubled); v5: new Figure 4, captions expanded, minor editorial improvements to the text