Effects of heterogeneity on cancer: a game theory perspective
Abstract
In this study, we explore interactions between cancer cells by using the hawk-dove game. We analyze the heterogeneity of tumors by considering games with populations composed of 2 or 3 types of cells. We determine what strategies are evolutionarily stable in the 2-type and 3-type population games and the corresponding expected payoffs. Our results show that the payoff of the best-off cell in the 2-type population game is higher than that of the best-off cell in the 3-type population game. Translating these mathematical findings to the field of oncology suggests that a branching-type tumor pursues a less aggressive course than a punctuated-type one. Some histological and genomic data of clear cell renal cell carcinomas are consistent with these results.
Keywords
Cite
@article{arxiv.2202.02211,
title = {Effects of heterogeneity on cancer: a game theory perspective},
author = {Annick Laruelle and André Rocha and Claudia Manini and José I López and Elena Inarra},
journal= {arXiv preprint arXiv:2202.02211},
year = {2022}
}
Comments
16 pages, 3 figures