Effect of hypertension on low-density lipoprotein transport within a multi-layered arterial wall: modelling consistent with experiments
Biological Physics
2016-04-14 v1 Subcellular Processes
Abstract
The influence of hypertension on low-density lipoproteins intake into the arterial wall is an important factor for understanding mechanisms of atherosclerosis. It has been experimentally observed that the increased pressure leads to the higher level of the LDL inside the wall. In this paper we attempt to construct a model of the LDL transport which reproduces quantitatively experimental outcomes. We supplement the well known four-layer arterial wall model to include two pressure induced effects: the compression of the intima tissue and the increase of the fraction of leaky junctions. We demonstrate that such model can reach the very good agreement with experimental data.
Keywords
Cite
@article{arxiv.1604.03735,
title = {Effect of hypertension on low-density lipoprotein transport within a multi-layered arterial wall: modelling consistent with experiments},
author = {Katarzyna Jesionek and Aleksandra Slapik and Marcin Kostur},
journal= {arXiv preprint arXiv:1604.03735},
year = {2016}
}
Comments
19p 7 fig