English

Dynamical model based on finite stacking enthalpies for homogeneous and inhomogeneous DNA thermal denaturation

Biological Physics 2007-05-23 v2

Abstract

We present a nonlinear dynamical model for DNA thermal denaturation, which is based on the finite stacking enthalpies used in thermodynamical nearest-neighbour calculations. Within this model, the finiteness of stacking enthalpies is shown to be responsible for the sharpness of calculated melting curves. Transfer-integral and molecular dynamics calculations are performed to demonstrate that the proposed model leads to good agreement with known experimental results for both homogeneous and inhomogeneous DNA.

Keywords

Cite

@article{arxiv.physics/0508189,
  title  = {Dynamical model based on finite stacking enthalpies for homogeneous and inhomogeneous DNA thermal denaturation},
  author = {Marc Joyeux and Sahin Buyukdagli},
  journal= {arXiv preprint arXiv:physics/0508189},
  year   = {2007}
}