Optical coherence tomography offers astounding opportunities to image the complex structure of living tissue, but lacks functional information. We present dynamic full-field optical coherence tomography to image living human induced pluripotent stem cell-derived retinal organoids non-invasively. Colored images with an endogenous contrast linked to organelle motility are generated, with sub-micrometer spatial resolution and millisecond temporal resolution, opening an avenue to identify specific cell types in living tissue via their function.
@article{arxiv.1912.04052,
title = {Dynamic full-field optical coherence tomography: 3D live-imaging of retinal organoids},
author = {Jules Scholler and Kassandra Groux and Olivier Goureau and José-Alain Sahel and Mathias Fink and Sacha Reichman and Claude Boccara and Kate Grieve},
journal= {arXiv preprint arXiv:1912.04052},
year = {2020}
}