Drug absorption through a cell monolayer: a theoretical work on a non-linear three-compartment model
Abstract
The subject of analysis is a non-linear three-compartment model, widely used in pharmacological absorption studies. It has been transformed into a general form, thus leading automatically to an appropriate approximation. This made the absorption profile accessible and expressions for absorption times, apparent permeabilities and equilibrium values were given. These findings allowed a profound analysis of results from non-linear curve fits and delivered the dependencies on the systems' parameters over a wide range of values. The results were applied to an absorption experiment with multidrug transporter-affected antibiotic CNV97100 on Caco-2 cell monolayers.
Keywords
Cite
@article{arxiv.0805.3757,
title = {Drug absorption through a cell monolayer: a theoretical work on a non-linear three-compartment model},
author = {Niko Komin and Raúl Toral},
journal= {arXiv preprint arXiv:0805.3757},
year = {2010}
}
Comments
21 pages, 8 figures (v4: detailed definition of the treated model - additional information about limitations)