Distinguishing between paediatric brain tumour types using multi-parametric magnetic resonance imaging and machine learning: a multi-site study
Abstract
The imaging and subsequent accurate diagnosis of paediatric brain tumours presents a radiological challenge, with magnetic resonance imaging playing a key role in providing tumour specific imaging information. Diffusion weighted and perfusion imaging are commonly used to aid the non invasive diagnosis of paediatric brain tumours, but are usually evaluated by expert qualitative review. Quantitative studies are mainly single centre and single modality. The aim of this work was to combine multi centre diffusion and perfusion imaging, with machine learning, to develop machine learning based classifiers to discriminate between three common paediatric tumour types. The results show that diffusion and perfusion weighted imaging of both the tumour and whole brain provide significant features which differ between tumour types, and that combining these features gives the optimal machine learning classifier with greater than 80 percent predictive precision. This work represents a step forward to aid in the non invasive diagnosis of paediatric brain tumours, using advanced clinical imaging.
Cite
@article{arxiv.1910.09247,
title = {Distinguishing between paediatric brain tumour types using multi-parametric magnetic resonance imaging and machine learning: a multi-site study},
author = {James T. Grist and Stephanie Withey and Lesley MacPherson and Adam Oates and Stephen Powell and Jan Novak and Laurence Abernethy and Barry Pizer and Richard Grundy and Simon Bailey and Dipayan Mitra and Theodoros N. Arvanitis and Dorothee P. Auer and Shivaram Avula and Andrew C Peet},
journal= {arXiv preprint arXiv:1910.09247},
year = {2019}
}
Comments
22 pages, 7 figures and tables