Cells respond to biophysical and biochemical signals. We developed a composite filament from collagen and silica particles modified to interact with collagen and/or present a laminin epitope (IKVAV) crucial for cell-matrix adhesion and signal transduction. This combines scaffolding and signaling and shows that local tuning of collagen organization enhances cell differentiation.
@article{arxiv.2001.10437,
title = {Differentiation of neural-type cells on multi-scale ordered collagen-silica bionanocomposites},
author = {Nicolas Debons and Dounia Dems and Christophe Hélary and Sylvain Le Grill and Lise Picaut and Flore Renaud and Nicolas Delsuc and Marie-Claire Schanne-Klein and Thibaud Coradin and Carole Aimé},
journal= {arXiv preprint arXiv:2001.10437},
year = {2020}
}