Design and analysis considerations for a sequentially randomized HIV prevention trial
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2020-03-24 v1
Abstract
TechStep is a randomized trial of a mobile health interventions targeted towards transgender adolescents. The interventions include a short message system, a mobile-optimized web application, and electronic counseling. The primary outcomes are self-reported sexual risk behaviors and uptake of HIV preventing medication. In order that we may evaluate the efficacy of several different combinations of interventions, the trial has a sequentially randomized design. We use a causal framework to formalize the estimands of the primary and key secondary analyses of the TechStep trial data. Targeted minimum loss-based estimators of these quantities are described and studied in simulation.
Cite
@article{arxiv.1906.09304,
title = {Design and analysis considerations for a sequentially randomized HIV prevention trial},
author = {David Benkeser and Keith Horvath and Cathy Reback and Joshua Rusow and Michael Hudgens},
journal= {arXiv preprint arXiv:1906.09304},
year = {2020}
}