We study S-wave interactions in the I(Jp)=1/2(1/2−)ΛcK+−pDs system on the basis of the coupled-channel HAL QCD method. The potentials which are faithful to QCD S-matrix below the pD∗ threshold are extracted from Nambu-Bethe-Salpeter wave functions on the lattice in Flavor SU(3) Limit. For the simulation, we employ 3-flavor full QCD gauge configurations on a (1.93fm)3 volume at mπ≃872 MeV. %\textcolor{red}{For the charm quark, the relativistic heavy quark action is employed to treat its dynamics on the lattice}. We present our results of the S-wave coupled-channel potentials for the ΛcK+−pDs system in the 1/2(1/2−) state as well as scattering observables obtained from the extracted potential matrix. We observe that the coupling between ΛcK+ and pDs channels is weak. The phase shifts and scattering length obtained from the extracted potential matrix show that the ΛcK+ interaction is attractive at low energy and stronger than the pDs interaction though no bound state at mπ≥872 MeV.