We have explored morphology of DNA molecules bound with Cu-complexes of piroxicam molecules, a non-steroidal anti-inflammatory drug (NSAID), under one-dimensional confinement of thin films and have studied the effect of counterions present in a buffer. X-ray reflectivity at and away from the Cu K absorption edge and atomic force microscopy studies reveal that confinement segregates the drug molecules preferentially in a top layer of the DNA film, and counterions enhance this segregation.
@article{arxiv.1404.1430,
title = {Counterion Effects on Nano-confined Metal-Drug-DNA Complexes},
author = {Nupur Biswas and Sreeja Chakraborty and Alokmay Datta and Munna Sarkar and Mrinmay K. Mukhopadhyay and Mrinal K. Bera and Hideki Seto},
journal= {arXiv preprint arXiv:1404.1430},
year = {2016}
}