Continual Reassessment and Related Dose-Finding Designs
Abstract
During the last twenty years there have been considerable methodological developments in the design and analysis of Phase 1, Phase 2 and Phase 1/2 dose-finding studies. Many of these developments are related to the continual reassessment method (CRM), first introduced by O'Quigley, Pepe and Fisher (\citeyearQPF1990). CRM models have proven themselves to be of practical use and, in this discussion, we investigate the basic approach, some connections to other methods, some generalizations, as well as further applications of the model. We obtain some new results which can provide guidance in practice.
Cite
@article{arxiv.1011.6251,
title = {Continual Reassessment and Related Dose-Finding Designs},
author = {John O'Quigley and Mark Conaway},
journal= {arXiv preprint arXiv:1011.6251},
year = {2010}
}
Comments
Published in at http://dx.doi.org/10.1214/10-STS332 the Statistical Science (http://www.imstat.org/sts/) by the Institute of Mathematical Statistics (http://www.imstat.org)