Conserved symmetries in noncommutative quantum mechanics

We consider a problem of the consistent deformation of physical system introducing a new features, but preserving its fundamental properties. In particular, we study how to implement the noncommutativity of space-time without violation of the rotational symmetry in quantum mechanics or the Lorentz symmetry in f{i}eld theory. Since the canonical (Moyal) noncommutativity breaks the above symmetries one should work with more general case of coordinate-dependent noncommutative spaces, when the commutator between coordinates is a function of these coordinates. F{i}rst we describe in general lines how to construct the quantum mechanics on coordinate-dependent noncommutative spaces. Then we consider the particular examples: the Hydrogen atom on rotationally invariant noncommutative space and the Dirac equation on covariant noncommutative space-time.