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Configurations in the Euclidean space related to the 3D genome reconstruction problem from partially phased data

Algebraic Geometry 2024-05-01 v2

Abstract

A motivation for studying the following problems comes from applications to Biology; see \cite{cifuentes20233d}. In the 33-dimensional Euclidean space E3{\bf{E}}^3, fix six pairwise distinct points \begin{equation*} \label{eqA} \begin{array}{ccc} A=(a_1,a_2,a_3), & B=(b_1,b_2,b_3), & C=(c_1,c_2,c_3), \\ D=(d_1,d_2,d_3), & E=(e_1,e_2,e_3), & F=(f_1,f_2,f_3) \end{array} \end{equation*} together with two further points X=(x1,x2,x3)X^*=(x_1^*,x_2^*,x_3^*) and Y=(y1,y2,y3)Y^*=(y_1^*,y_2^*,y_3^*) in E3\mathbf{E}^3. We aim to show that System ()(*) consisting of the following six equations in the unknowns X=(x1,x2,x3)X=(x_1,x_2,x_3) and Y=(y1,y2,y3)Y=(y_1,y_2,y_3) \begin{equation} \label{egy} \frac{1}{\|X-T\|^2} +\frac{1}{\|Y-T\|^2}=\frac{1}{\|X^*-T\|^2} +\frac{1}{\|Y^*-T\|^2}, \quad T\in\{A,B,\ldots,F\}. \end{equation} has only finitely many solutions provided that both of the following two conditions are satisfied: (i) no four of the fixed points A,B,C,D,E,FA,B,C,D,E,F are coplanar; (ii) no four of the six spheres of center TT and radius 1/kT1/\sqrt{k_T} with \begin{equation} \label{kxy} k_T=\frac{1}{\|X^*-T\|^2} +\frac{1}{\|Y^*-T\|^2} \end{equation} share a common point in E3{\bf{E}}^3. Furthermore, we exhibit configurations ABCDEFXYABCDEFX^*Y^*, showing that (i) is also necessary. This result is an improvement on \cite[Theorem 1]{cifuentes20233d} where the finiteness of solutions of System ()(*) is only ensured for sufficiently generic choices of the points A,B,,F,X,Y.A,B,\ldots,F,X^*,Y^*. We also show if System ()(*) has finitely many solutions and System ()(*) extended with T{A,B,,F,G}T\in\{A,B,\ldots,F,G\} has some solutions other than (X,Y)(X^*,Y^*) and (Y,X)(Y^*,X^*) then GG lies on an explicitly given affine variety WR3W\subsetneqq \mathbb{R}^3 only depending on {A,B,,F}\{A,B,\ldots,F\}. This result proves the \cite[Conjecture 1]{cifuentes20233d}.

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Cite

@article{arxiv.2403.00407,
  title  = {Configurations in the Euclidean space related to the 3D genome reconstruction problem from partially phased data},
  author = {Annachiara Korchmaros},
  journal= {arXiv preprint arXiv:2403.00407},
  year   = {2024}
}

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14 pages