A computational model of aquaporin regulation in cancer cells has been constructed as a Qualitative Network in the software BioModelAnalyzer (BMA). The model connects some important aquaporins expressed in human cancer to common phenotypes via a number of fundamental, dysregulated signalling pathways. Based on over 60 publications, this model can not only reproduce the results reported in a discrete, qualitative manner, but also reconcile the seemingly incompatible phenotype with research consensus by suggesting molecular mechanisms accountable for it. Novel predictions have also been made by mimicking real-life experiments in the model.
@article{arxiv.1712.08265,
title = {Computational Modelling of Aquaporin Co-regulation in Cancer},
author = {Junzhe Zhao and Benjamin A. Hall},
journal= {arXiv preprint arXiv:1712.08265},
year = {2018}
}
Comments
Data is used without full credit and explicit agreement from another author and fellow experimentalists